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Associated Factors Of Post Thrombotic Syndrome In Patients With Deep Vein Thrombosis

I Gusti Agung Bagus Krisna Wibawa1*, Ida Bagus Ananta Wijaya2, I Nyoman Golden2

Background: Post-thrombotic syndrome (PTS) is a chronic complication of deep vein thrombosis (DVT) which results in decreased quality of life and high health-care costs. Age, gender, obesity, type 2 diabetes mellitus, ipsilateral DVT, history of surgery, use of anticoagulants, and history of malignancy are risk factors that associated with the occurrence of PTS.

Method: This case-control study was conducted in 2019 at Sanglah Hospital, Denpasar. The presence or absence of risk factors of patients who met the inclusion criteria would then be obtained from medical records. Univariate, bivariate and multivariate analyzes were performed using SPSS.

Results: From 48 patients, 60.5% of the subjects were ≤60 years old and 56.3% were female. In the bivariate analysis it was found that not using anticoagulants (OR: 7.28; 95% CI = 2.03-26.10; p = 0.00), obesity (OR: 26.4; 95% CI = 5.54- 125.7; p = 0.00) and history of surgery (OR: 4.94; 95% CI = 0.92-26.41; p = 0.04) were risk factors associated with the incidence of PTS. Meanwhile, in the multivariate analysis, it was found that obesity status was the most dominant factor in which obese patients had a 31.91-fold higher risk of experiencing PTS (95% CI: 4,623-220.3; p = 0.00).

Conclusion: Obesity, not using anticoagulants and history of surgery were factors that were independently associated with the occurrence of PTS in patients with DVT.

Keyword: obesity, anticoagulant, history of surgery, post-thrombotic syndrome, deep vein thrombosis

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